ssl.RAND_bytes()

ssl.RAND_bytes(num)

Return num cryptographically strong pseudo-random bytes. Raises an SSLError if the PRNG has not been seeded with enough data or if the operation is not supported by the current RAND method. RAND_status() can be used to check the status of the PRNG and RAND_add() can be used to seed the PRNG.

For almost all applications os.urandom() is preferable.

Read the Wikipedia article, Cryptographically secure pseudorandom number generator (CSPRNG), to get the requirements of a cryptographically generator.